Title of Project
Workbench for micro-scale molecular imaging.
Description of Project
It is a joint research project between Biomolex (as coordinator), The University of Lund (Sweden) and Bioinvent International (Sweden). A project grant from Eurostars (EU) was given.
Short Summary of Project
The main goal is to develop a unique workbench for micro-scale molecular imaging, and to use this platform to gain a better understanding of antibodies mode of action in relation to the biology of the targeted disease
Long Summary
The main goal is to develop a unique workbench for micro-scale molecular imaging, combining new imaging technology based on a double sided silicon detector (DSSD), advanced software modules and analysis protocols. Further more to use this workbench to establish validated methods for:
- early validation of in vivo behavior of drug candidate antibodies
- evaluation of in situ antigen distribution in tumor and inflammation in animal models
- evaluation of suitable biomarkers for in vivo imaging of tumor and inflammation disease.
The new workbench will support micro-scale imaging of the distribution of radio-labeled compounds in tissue sections, i.e. digital autoradiography. This will allow research laboratories in industry and academia to improve the quality and quantity of imaging analysis for ex vivo studies, in addition to reducing the amount of test animals. We will develop a robust hardware and software solution which allows the end-user to produce scientifically significant results under a wide variety of conditions, minimizing the threshold for end-users in terms of imaging and/or radiation physics expertise.